Enantioselective Michael addition of isobutyraldehyde to nitroalkenes organocatalyzed by chiral primary amine-guanidines
نویسندگان
چکیده
منابع مشابه
Simple chiral sulfonamide primary amine catalysed highly enantioselective Michael addition of malonates to enones.
A chiral sulfonamide primary amine-organocatalysed, highly enantioselective Michael addition of malonates to enones has been developed. This reaction afforded the corresponding products in excellent yields (up to 99%) and excellent enantioselectivity (up to 99% ee).
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The diastereo- and enantioselective direct vinylogous Michael addition reaction of γ-substituted butenolides to 2-enoylpyridines has been achieved. A range of γ,γ-disubstituted butenolide derivatives, bearing two consecutive tri- and tetrasubstituted stereogenic centers, were readily obtained in good yields with excellent stereoselectivities (up to >99 : 1 dr and >99% ee).
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ژورنال
عنوان ژورنال: Tetrahedron: Asymmetry
سال: 2014
ISSN: 0957-4166
DOI: 10.1016/j.tetasy.2014.02.006